Similarly, earlier research revealed neurochemical alterations in the brain of neonatal male rats orally exposed to 10 and 20 mg Mn/kg bw/day (Deskin et al, 1980) and adjustments in motor-exercise of male Sprague-Dawley rats (hyperactivity in the first month and hypoactivity from months 7 to
at concentrations of 0,1 and 5 mg Mn/ml drinking water (Bonilla, 1984). Alkaline phosphatase is an enzyme having numerous isoforms, that are produced in the leukocytes, liver, bone, gut, placenta and Regan (carcinoma). Psychiatric and behavioural issues are current in up to 90% of patients with dementia
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