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Etiology The etiology of heart defects is heterogeneous and probably is dependent upon the interaction of a number of genetic and environmental components, together with maternal diabetes mellitus or collagen illness, exposure to medicine similar to lithium, and viral infections corresponding to rubella. In fastidiously chosen patients survival using this technique can attain about 60% in five years which is comparable to the final heart transplant population [121],[128],[129]. Autoantibodies directed against impartial or negatively charged phospholipids including anticardiolipin antibodies (aCl) and lupus anticoagulant treatment xdr tb guidelines
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